環開きポリメリゼーションによるポリラクチド製薬ナノ粒子の制御製剤
1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Journal of the American Chemical Society
|March 14, 2009
まとめ
研究者は,制御されたポリメリゼーションを使用してドクソルビシン-ポリラクチド (ドクソ-PLA) ナノ粒子を作成するための新しい方法を開発しました. このテクニックは,効率的な薬物充填と持続的な放出を可能にし,標的型薬物投与システムに対する有望なアプローチを提供します.
科学分野:
- ポリマー化学のポリマー化学について
- ナノテクノロジー ナノテクノロジー
- 薬物の配達 薬物の配達
背景:
- ドクソルビシン (ドクソ) は強力な化学療法薬ですが,副作用によって使用が制限されています.
- ナノ粒子などの効果的な薬物投与システムの開発は,標的がん治療に不可欠です.
- ポリラクチド (PLA) は生物適合性ポリマーで,薬剤投与アプリケーションで使用されることが多い.
研究 の 目的:
- ドクソルビシン-ポリラクチド (ドクソ-PLA) 結合ナノ粒子 (NCs) の製剤のためのユニークな方法を開発する.
- 乳酸 (LA) の化学的および地域選択的ポリメリゼーションを達成するために,新しいイニシアターシステムを使用します.
- 制御されたサイズ,薬物負荷,および持続的な放出特性を有する Doxo-PLA NC を作成します.
主な方法:
- 乳酸 (LA) の Doxo/(BDI) ZnN ((TMS) ((2) 媒介の化学的および地域選択的ポリメリゼーションを使用した.
- ナノプレシピテーションを用いて,ドクソ-PLA結合ナノ粒子 (NC) を形成しました.
- ポリメリゼーションの選択性と製品形成に対するステリック・バルクと金属触媒の影響を調査した.
主要な成果:
- ほぼ100%のドクソルビシン (ドクソ) 負荷効率と100%のラクチド (LA) 変換を達成しました.
- 高い化学選択性を示し,1-ピレネメタノール (Pyr-OH) が消費され,共結合され,1-ピレネメチラミン (Pyr-NH(2) は無傷のままである.
- 150nm未満のサイズと狭い粒子のサイズ分布で,パストリリースなしの持続的なドクソ放出を示す,製剤ドクソ-PLANCs.
結論:
- 開発されたDOXO/BDI/ZnN/TMS) 2媒介LAポリメリゼーションは,DOXO-PLA結合体を生成するための制御された方法を提供します.
- その結果生成されるナノ粒子は,優れた薬物負荷,制御された粒子のサイズ,持続的な薬物放出プロファイルを示しています.
- この多用途な方法は,ヒドロキシル含有剤をポリエステルに結合させ,高度なナノ粒子配送システムを形成するための大きな可能性を秘めています.
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