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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Updated: Jun 24, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

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Published on: August 29, 2012

移植対宿主病 (Graft-versus-host disease) とは,移植対宿主病 (GVHD) とは,移植対宿主病 (GVHD) とは,移植対宿主病 (GVHD) とは,移植対宿主病 (GVHD) とは,移植対宿主病

James L M Ferrara1, John E Levine, Pavan Reddy

  • 1University of Michigan, Pediatrics and Internal Medicine, Blood and Marrow Transplantation Program, Ann Arbor, MI 48109-5942, USA. ferrara@umich.edu

Lancet (London, England)
|March 14, 2009
PubMed
まとめ
この要約は機械生成です。

血液形成細胞移植 (HCT) は,複数の臓器に影響を与える深刻な合併症である移植対宿主疾患 (GVHD) に繋がる可能性があります. このレビューは,GVHDの原因,病理生理学,移植患者の管理戦略をカバーしています.

さらに関連する動画

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR
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関連する実験動画

Last Updated: Jun 24, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR
06:06

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR

Published on: May 23, 2019

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

科学分野:

  • 血液学 ヘマトロジ
  • 免疫学 免疫学とは
  • 移植医療 移植医療について

背景:

  • ヘモポエティック細胞移植 (HCT) は,高リスクの血液学的悪性腫瘍および遺伝疾患の重要な治療法です.
  • 移植対宿主疾患 (GVHD) は,HCT後の主要な免疫学的合併症であり,様々な臓器に影響を及ぼします.
  • HCT後の継続的な免疫抑制を必要とする患者の数は増加しており,感染症やその他の合併症のリスクを高めています.

研究 の 目的:

  • GVHDの危険因子と原因に関する現在の理解をレビューする.
  • GVHDの病理生理学に関与する細胞およびサイトカインネットワークを調査する.
  • GVHDの予防,治療,およびサポートケア戦略を要約する.

主な方法:

  • GVHDの危険因子,病理生理学,および管理に関する文献レビュー.
  • GVHDにおける細胞とサイトカイン経路の分析.
  • 予防,治療,およびサポートケアに関する現在のエビデンスの統合.

主要な成果:

  • GVHDは,胃腸,肝臓,皮膚,肺に影響を与える複雑な免疫的メカニズムを伴う.
  • HCT後の免疫抑制療法は,感染症に対する脆弱性を高めます.
  • 効果的な管理には,予防,治療,サポートケアを含む多面的なアプローチが必要です.

結論:

  • GVHDの病理生理学を理解することは,より良い治療戦略の開発に不可欠です.
  • 総合的な管理計画は,HCT受給者の成果を改善するために不可欠です.
  • GVHDに関する継続的な研究は,移植医療の進歩に不可欠です.