カカオと心血管の健康
Roberto Corti1, Andreas J Flammer, Norman K Hollenberg
1Cardiovascular Center, Cardiology, University Hospital, Raemistrasse 100, CH-8091 Zurich, Switzerland. roberto.corti@usz.ch
Circulation
|March 18, 2009
まとめ
カカオの摂取は,血圧と血管機能の改善により,心臓血管の健康を改善する可能性があります. 将来の研究では,窒素酸化物の活性化と抗酸化作用を含む,潜在的な臨床応用のためのメカニズムを探求しています.
科学分野:
- 心血管科学 心血管科学
- 栄養学的流行病学について
- 薬理学 薬理学とは
背景:
- 植物由来食品の摂取は,冠動脈疾患や脳卒中などの心血管疾患のリスク低下と関連しています.
- カカオは,これらの心臓保護効果の潜在的な媒介者として特定されています.
- 新興の研究によると,カカオは血圧,インスリン抵抗性,血管/血小板機能に良い影響を与えると示唆されています.
研究 の 目的:
- カカオの心血管への影響に関する既存のデータをレビューする.
- カカオの利点の基礎となる提案されたメカニズムを概説する.
- カカオの消費による潜在的な臨床的影響を強調する.
主な方法:
- 疫学および実験研究の文献レビュー.
- 提案された生物学的経路の分析.
- 臨床的アウトカムに関する現在の証拠の統合.
主要な成果:
- 疫学研究は,カカオを含む植物由来食品と心血管疾患のリスクの低下との関連性を支持しています.
- カカオの摂取は,血圧,インスリン感受性,内皮機能に有益な効果を示しています.
- 潜在的なメカニズムには,酸化窒素経路の活性化,抗酸化,および抗炎症作用が含まれます.
結論:
- カカオの消費は,心血管疾患に有望な利点を示しています.
- そのメカニズムには,内皮機能の改善と酸化ストレス減少が含まれる.
- 循環器の健康管理におけるカカオ摂取に関する臨床ガイドラインを確立するために,さらなる調査が必要である.
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