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Updated: Jun 24, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
11:13

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

ヴィンブラスティン,ヴィンクリスティン,関連する天然製品,および主要な構造類似物の総合合成

Hayato Ishikawa1, David A Colby, Shigeki Seto

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|March 19, 2009
PubMed
まとめ

この研究では,カタランチンとヴィンドリンを直接結合してヴィンブラスティンを合成し,80%以上の収穫率を達成する新しい方法について詳細に説明しています. この方法はまた,ビンクリスティンおよび関連する類似剤へのアクセスを提供し,それらの生物学的活動に関する洞察を提供します.

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