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Updated: Jun 23, 2026

A cGMP-applicable Expansion Method for Aggregates of Human Neural Stem and Progenitor Cells Derived From Pluripotent Stem Cells or Fetal Brain Tissue
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A cGMP-applicable Expansion Method for Aggregates of Human Neural Stem and Progenitor Cells Derived From Pluripotent Stem Cells or Fetal Brain Tissue

Published on: June 15, 2014

DISC1は,神経生成においてGSK3βと連携しています

Guo-li Ming1, Hongjun Song

  • 1Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gming1@jhmi.edu

Cell
|March 24, 2009
PubMed
まとめ

障害性統合失調症1 (DISC1) タンパク質は,神経原始細胞の増殖を調節する. この発見は,遺伝的感受性が精神疾患にどのように貢献するかについての新しい洞察を提供します.

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Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...