アスピリン,サリチラート,がん
Peter C Elwood1, Alison M Gallagher, Garry G Duthie
1School of Medicine, Cardiff University, Cardiff, UK.
Lancet (London, England)
|March 31, 2009
まとめ
アスピリンと非ステロイド性抗炎症薬は,大腸がんのリスクを減らす可能性があります. これらの発見を確認し,がん予防のためのメカニズムを探求するためにさらなる研究が必要です.
科学分野:
- 腫瘍学 腫瘍学
- 薬理学 薬理学とは
- 胃腸内科 胃腸内科
背景:
- 観察的研究と動物の研究は,アスピリンとNSAIDが大腸がんのリスクを下げる可能性があることを示唆しています.
- 倫理的な懸念は,ヒトのがん予防のための大規模なランダム化試験を妨げています.
研究 の 目的:
- ガン予防のためのアスピリンと天然サリチラートに関する既存の証拠を要約する.
- 潜在的なメカニズムと将来の研究方向について議論する.
主な方法:
- 機会主義的な試験を含む様々な情報源からの証拠のレビュー.
- 動物の研究とヒトの観察データの分析.
主要な成果:
- 一貫した証拠は,アスピリンおよび関連するNSAIDsで大腸がんのリスクが低下することを示唆しています.
- 機会主義的な試験は,アスピリンの使用が少なくとも10年経過した後に癌のリスクが低下することを示しています.
結論:
- アスピリンと天然の塩酸塩酸は,がんの予防,特に大腸がんの予防の可能性を示しています.
- メカニズムと臨床的影響に関するさらなる調査が必要である.
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