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関連する概念動画

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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関連する実験動画

Updated: Jun 24, 2026

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
10:52

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

Published on: June 5, 2015

iPS細胞の新たな見方

Shinya Yamanaka1

  • 1Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan. yamanaka@frontier.kyoto-u.ac.jp

Cell
|April 7, 2009
PubMed
まとめ

誘発性多能幹細胞 (iPS) は,医薬品と医薬品の巨大な可能性を秘めています. しかし,その治療的応用を完全に実現するには,大きな課題を克服する必要があります.

科学分野:

  • 幹細胞生物学 幹細胞生物学とは
  • 再生医学は再生医学である.
  • 細胞を再プログラムする.

背景:

  • 誘発性多能幹細胞 (iPS) は再生医療の有望な道を示しています.
  • その潜在的応用は,疾患モデリングや薬剤発見など,様々な治療分野に及ぶ.
  • iPS細胞技術の臨床実践への翻訳を妨げている大きな障害があります.

研究 の 目的:

  • 誘発性多能幹細胞 (iPS) の巨大な可能性を探求する.
  • iPS細胞の医療および医薬品の応用を妨げている主要な障害を特定し,分析する.
  • 将来の治療開発のために,これらの課題を克服するための洞察を提供するために.

主な方法:

  • iPS細胞技術に関する現在の文献のレビュー.
  • iPS細胞生成,分化,および安全性における報告された課題の分析.
  • 異なる再プログラミング戦略とその限界の比較評価.

主要な成果:

  • iPS細胞の広大な可能性は,複数の科学領域で認められています.
  • 特定された主要な障害には,再プログラム効率,遺伝的/表遺伝的安定性,腫瘍性が含まれています.
  • 生産のスケーラビリティとプロトコルの標準化は,医薬品アプリケーションにとって重要な懸念事項です.

さらに関連する動画

Efficient Generation and Editing of Feeder-free IPSCs from Human Pancreatic Cells Using the CRISPR-Cas9 System
09:16

Efficient Generation and Editing of Feeder-free IPSCs from Human Pancreatic Cells Using the CRISPR-Cas9 System

Published on: November 8, 2017

Generation of Mice Derived from Induced Pluripotent Stem Cells
11:56

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

関連する実験動画

Last Updated: Jun 24, 2026

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids
10:52

Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids

Published on: June 5, 2015

Efficient Generation and Editing of Feeder-free IPSCs from Human Pancreatic Cells Using the CRISPR-Cas9 System
09:16

Efficient Generation and Editing of Feeder-free IPSCs from Human Pancreatic Cells Using the CRISPR-Cas9 System

Published on: November 8, 2017

Generation of Mice Derived from Induced Pluripotent Stem Cells
11:56

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

結論:

  • 誘導性多能幹細胞 (iPS) は,巨大な可能性を持つ変革的技術を表しています.
  • 安全性,有効性,スケーラビリティに関連する課題を克服することは,臨床翻訳において極めて重要です.
  • iPS細胞の医療および製薬上の利点のすべてを開示するために,さらなる研究と開発が不可欠です.