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茶色の脂肪の代謝に関する新たな展開
Harriet Wallberg-Henriksson1, Juleen R Zierath
1Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, S-171 77 Stockholm, Sweden.
Cell
|April 7, 2009
まとめ
転写因子twist-1は,ミトコンドリア生体生成と茶色脂肪の熱生成の重要な原動力であるPGC-1αを否定的に調節する. この発見は,エネルギー支出を制御するフィードバックメカニズムを明らかにしています.
科学分野:
- 代謝と内分泌学について
- 分子生物学は分子生物学である.
- アディポス組織生物学
背景:
- ペロキシソーム増殖器活性化受容体ガンマ共活性化剤1-α (PGC-1alpha) は,茶色脂肪組織におけるミトコンドリア生体生成と熱生成に不可欠である.
- PGC-1αの調節を理解することは,エネルギー消費と代謝恒常性を制御するために不可欠です.
研究 の 目的:
- 茶色の脂肪組織におけるPGC-1αの新しいレギュレータを特定する.
- PGC-1αの活性が制御される分子メカニズムを解明する.
主な方法:
- PGC-1alpha.を調節するトランスクリプション因子の役割を調査した.
- 遺伝子発現とタンパク質の相互作用を評価するために分子生物学技術を活用しました.
主要な成果:
- 直接PGC-1alphaと相互作用し,抑制する転写因子としてtwist-1を特定した.
- twist-1がPGC-1α媒介遺伝子発現のネガティブなフィードバックレギュレータとして作用することを実証した.
- ミトコンドリアバイオゲネシスと発熱遺伝子のプログラムに対するtwist-1の影響を紹介した.
結論:
- Twist-1は,茶色の脂肪組織におけるPGC-1αの新種の負の調節剤である.
- この調節軸は,ミトコンドリア機能とエネルギー代謝の調節のための新しいターゲットを提供します.
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