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Updated: May 13, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

アセチル化により,突然変異したハンティングチンは,分解のためにオートファゴソームに標的にされます

Hyunkyung Jeong1, Florian Then, Thomas J Melia

  • 1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129, USA.

Cell
|April 7, 2009
PubMed
まとめ

K444における変異ハンティングチンタンパク質のアセチル化は,オートファギーの経由でそのクリアランスを強化し,ハンティントン病のモデルにおける有毒効果を逆転させます. この改変は,神経変性障害の予防に極めて重要です.

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Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy11:22

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Published on: June 27, 2018

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

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