Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
Mechanical Protein Functions01:58

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase.

Nature communications·2026
Same author

Free energy perturbations in enzyme kinetic models reveal cryptic epistasis.

PLoS computational biology·2026
Same author

Widespread promiscuous alkaline phosphatases underscore ancient microbial phosphite utilization.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Functional sub-states link conformational landscapes and protein evolution.

Current opinion in structural biology·2025
Same author

Stability of multi-species consortia during microbial metabolic evolution.

Evolution; international journal of organic evolution·2025
Same author

Exploring Large Protein Sequence Space through Homology- and Representation-based Hierarchical Clustering.

Molecular biology and evolution·2025
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Jun 24, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

タンパク質のダイナミズムと進化可能性

Nobuhiko Tokuriki1, Dan S Tawfik

  • 1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

Science (New York, N.Y.)
|April 11, 2009
PubMed
まとめ
この要約は機械生成です。

タンパク質は動的であり,適応可能であり,固定的ではありません. この柔軟性と機能的乱交性は,タンパク質の進化の鍵であり,新しい機能と構造を可能にします.

さらに関連する動画

A Practical Guide to Phage- and Robotics-Assisted Near-Continuous Evolution
05:08

A Practical Guide to Phage- and Robotics-Assisted Near-Continuous Evolution

Published on: January 12, 2024

関連する実験動画

Last Updated: Jun 24, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

A Practical Guide to Phage- and Robotics-Assisted Near-Continuous Evolution
05:08

A Practical Guide to Phage- and Robotics-Assisted Near-Continuous Evolution

Published on: January 12, 2024

科学分野:

  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.
  • 進化生物学の進化生物学について

背景:

  • 伝統的な見解:タンパク質は固定された構造と特定の機能を有する.
  • 観察:タンパク質は,新しい機能/構造の驚くべき適応性と進化を示しています.
  • 矛盾:固定された構造/機能モデルと観察されたタンパク質の可塑性.

研究 の 目的:

  • タンパク質の構造と機能の代替的な"先駆的な見方"を提案する.
  • タンパク質の進化性におけるタンパク質のダイナミズムと機能的乱交の役割を探求する.
  • タンパク質の包装が進化能力に与える影響を調査する.

主な方法:

  • 既存の文献に基づいた概念的枠組みの開発.
  • タンパク質の構成ダイナミクスと機能的乱交性の分析.
  • 初期のタンパク質の進化と将来の研究にダイナミック原理の抽象化.

主要な成果:

  • タンパク質は形状的にダイナミックで,機能的に乱交的である.
  • これらの性質は,タンパク質の進化能力の基礎である.
  • 包装が不良で乱れたタンパク質は,より高い進化性を示す.
  • ダイナミックビューは,新しい機能/折り畳みの進化の理解を容易にする.

結論:

  • タンパク質のダイナミズムと機能的乱交は,タンパク質の進化の中心にある.
  • タンパク質のダイナミクスを理解することは,進化の軌道を予測するために極めて重要です.
  • 将来の研究は,タンパク質のダイナミズムとその進化的影響に焦点を当てるべきである.