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Updated: May 10, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 30, 2010

レプリコンのダイナミクス,ドーパント・オリジンの発火,そしてダブル・ストランド・ブレイク・フォーキング形成後の端末フォークの整合性

Ylli Doksani1, Rodrigo Bermejo, Simona Fiorani

  • 1FIRC Institute of Molecular Oncology Foundation (IFOM-IEO Campus) and DSBB-Università degli Studi di Milano, Via Adamello 16, 20139 Milan, Italy.

Cell
|April 14, 2009
PubMed
まとめ

DNAの二重鎖断裂 (DSB) は,複製フォークを切り離し,不活性な起源発射または隣接複製を誘発し,ゲノム安定性を確保することができます. この研究では,Mre11-Tel1/ATM経路がS段階のターミナルフォークの完全性にとって重要なことを明らかにしました.

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