Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

High-resolution modelling of organic aerosol over Europe: exploring spatial and temporal variability and drivers.

Environment international·2026
Same author

Pontus-Mpemba Effects.

Physical review letters·2025
Same author

Direct neutrino-mass measurement based on 259 days of KATRIN data.

Science (New York, N.Y.)·2025
Same author

Silicon Drift Detectors for the Measurement and Reconstruction of Beta Spectra.

Sensors (Basel, Switzerland)·2025
Same author

Non-Abelian Anyon Statistics through ac Conductance of a Majorana Interferometer.

Physical review letters·2024
Same author

Mpemba Effects in Open Nonequilibrium Quantum Systems.

Physical review letters·2024

関連する実験動画

Updated: Jun 24, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

アリトモジェニック右心室心筋病変症

Cristina Basso1, Domenico Corrado, Frank I Marcus

  • 1University of Padua Medical School, Padua, Italy.

Lancet (London, England)
|April 14, 2009
PubMed
まとめ

アリズム発作性心筋症は,突然死を引き起こす遺伝性心疾患です. 遺伝子スクリーニングとリスクの階層化による早期発見は,罹患家族における有害な結果の予防に不可欠です.

科学分野:

  • 心臓病学 心臓病学
  • 遺伝学 遺伝学とは
  • 遺伝性心疾患 遺伝性心疾患とは

背景:

  • アリズム発生性右心室性心筋病変 (ARVC) は,珍しい遺伝性心筋疾患である.
  • これは,若者やアスリートにおける突然の心臓発作による死亡の重要な原因である.
  • デスマソームタンパク質の遺伝的変異が関与しており,遺伝的に決定された心筋ジストロフィーとして分類されています.

研究 の 目的:

  • アリズム不振性心筋症候群の総合的な概要を提供するために.
  • 早期発見と予防のための診断上の課題と臨床目標を強調する.
  • 家族の遺伝子スクリーニングの役割を強調する.

主な方法:

  • アリズム異常性心筋症の現在の理解のレビュー.
  • 診断基準の記述には,心室の変化,心電図の異常,心律失調,生検の結果などが含まれます.
  • 遺伝子スクリーニングとリスク分層化戦略の議論.

主要な成果:

  • 標準化された診断基準は存在するが,病気の早期発見に対する感度が欠如している可能性がある.
  • 左心室の関わりは一般的であり,リズム不振性心筋症候群という用語を支持する.

さらに関連する動画

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
10:18

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Published on: February 1, 2022

関連する実験動画

Last Updated: Jun 24, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
10:18

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Published on: February 1, 2022

  • カスケード遺伝子スクリーニングは,年齢関連の浸透性のために終身追跡を必要とする無症状のキャリアを特定します.
  • 結論:

    • アリズム発作性心筋症は,早期発見と管理を必要とする遺伝的に決定された疾患です.
    • 予防策には,運動制限,薬物療法,デバイス療法などがあります.
    • 遺伝子のスクリーニングは,リスクのある家族を特定し,早期の介入を可能にするために不可欠です.