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Updated: May 1, 2026

Examination of the Telomere G-overhang Structure in Trypanosoma brucei
15:25

Examination of the Telomere G-overhang Structure in Trypanosoma brucei

Published on: January 27, 2011

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酵母エンドヌクレアースによって発生したDNA断裂は,Trypanosoma bruceiの抗原スイッチングを誘発する

Catharine E Boothroyd1, Oliver Dreesen, Tatyana Leonova

  • 1Laboratory of Lymphocyte Biology, The Rockefeller University, New York, New York 10065, USA.

Nature
|April 17, 2009
PubMed
まとめ

トリパノソーマ・ブルセイは,変異性表面グリコタンパク質 (VSG) スイッチングを通じて免疫反応を回避する. VSG遺伝子の近くにDNA二重鎖断裂 (DSB) を導入すると,スイッチング頻度が大幅に増加し,DSBがこのプロセスの重要な中間体であることを明らかにします.

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