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Updated: Jun 24, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
06:50

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

タンパク質相互作用特異性の設計により,選択的なbZIP結合ペプチドが得られる

Gevorg Grigoryan1, Aaron W Reinke, Amy E Keating

  • 1MIT Department of Biology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Nature
|April 17, 2009
PubMed
まとめ

研究者は,特定のタンパク質の相互作用を設計するためのコンピューティングフレームワークを開発し,ヒトの基本領域のルシンのジッパー (bZIP) 転写因子のペプチドパートナーを成功裏に特定しました. この方法は,タンパク質の設計と治療開発を進めるための大きな可能性を示しています.

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

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