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関連する概念動画

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Free-falling Bodies: Introduction01:07

Free-falling Bodies: Introduction

All objects, neglecting air resistance, fall with the same acceleration towards the Earth's center due to the force exerted by the Earth's gravity. This experimentally determined fact is unexpected because we are so accustomed to the effects of air resistance and friction that we expect light objects to fall slower than heavier ones. People believed that a heavier object had a greater acceleration when falling until Galileo Galilei (1564–1642) proved otherwise. We now know this is not the case.
Free-falling Bodies: Example01:05

Free-falling Bodies: Example

An object falling without any air resistance under the influence of gravitational force is said to be in free-fall. For free-falling bodies, the acceleration due to gravity is constant, irrespective of their mass. Free-fall is experienced not only by objects falling downward, but also by all objects whose motion is influenced by gravitational force alone. The dynamics of free-fall motion can be calculated using kinematic equations of motion, since free-fall acceleration is constant.
The...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cellular Injury IlI: Cellular Death01:11

Cellular Injury IlI: Cellular Death

Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...

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Updated: Jun 11, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

堕落した不死の者.

Tomek Swigut1, Joanna Wysocka

  • 1Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

Cell
|April 22, 2009
PubMed
まとめ
この要約は機械生成です。

体細胞の遺伝子発現記憶は,染色体改変によって生殖系でリセットされます. ヒストン脱メチラーゼLsd1/Spr-5は,虫の世代を超えて生殖細胞の表遺伝的安定性と生存能力を維持することができる.

さらに関連する動画

Isolation and Immortalization of Patient-derived Cell Lines from Muscle Biopsy for Disease Modeling
11:26

Isolation and Immortalization of Patient-derived Cell Lines from Muscle Biopsy for Disease Modeling

Published on: January 18, 2015

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

関連する実験動画

Last Updated: Jun 11, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Isolation and Immortalization of Patient-derived Cell Lines from Muscle Biopsy for Disease Modeling
11:26

Isolation and Immortalization of Patient-derived Cell Lines from Muscle Biopsy for Disease Modeling

Published on: January 18, 2015

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells
12:17

Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells

Published on: January 2, 2016

科学分野:

  • エピジェネティクス エピジェネティクス
  • 発達生物学 発達生物学とは
  • 遺伝学 遺伝学とは

背景:

  • ソマティック細胞は,通常,生殖系再プログラム中に表遺伝的記憶を消去します.
  • このプロセスは,重要なクロマチンの改変を伴う.
  • 生殖の成功には,生殖細胞における表遺伝的安定性の維持が不可欠である.

研究 の 目的:

  • ヒストンデメチラーゼLsd1/Spr-5が虫の生殖線表遺伝子リセットにおける役割を調査する.
  • Lsd1/Spr-5が,生殖細胞の表遺伝的安定性と生存能力を維持するのにどのように貢献するのかを理解する.

主な方法:

  • この研究では,モデル生物*C. elegans*での遺伝子分析と分子技術が関与した可能性が高い.
  • 生殖細胞におけるLsd1/Spr-5の機能を調査する.
  • クロマチンの改変と表遺伝子遺伝への影響を評価する.

主要な成果:

  • カッツ et al. カッツ et al. (2009年) は,LSD1/Spr-5が体内の遺伝子発現の生殖線リセットに役割を果たしていることを示しています.
  • このヒストン脱メチラーゼは,生殖細胞の表遺伝的安定性の低下を防ぐことに関与しているようです.
  • この発見は,Lsd1/Spr-5が,世代を超えて生殖細胞の生存性を確保するために重要であることを示唆しています.

結論:

  • ヒストンデメチラーゼLsd1/Spr-5は,生殖細胞のエピジェネティック再プログラミングの重要なプロセスに関与しています.
  • Lsd1/Spr-5の活動は,生殖細胞の表遺伝的完全性を維持するために不可欠です.
  • このメカニズムは,生殖の成功に不可欠なエピジェネティック情報の安定した継承を保証します.