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Updated: Jun 16, 2026

Ferric Chloride-induced Murine Thrombosis Models
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血小板マトリックスメタロプロテアゼ-1は,暗号的リガンド部位でPAR1を活性化することによって,血栓形成を媒介する

Vishal Trivedi1, Adrienne Boire, Boris Tchernychev

  • 1Department of Medicine, Tufts University School of Medicine, Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

Cell
|April 22, 2009
PubMed
まとめ

血小板マトリックスメタロプロテアゼ-1 (MMP-1) は,血小板のプロテアゼ活性化受容体-1 (PAR1) を活性化させ,その結合を促進する. このMMP-1-PAR1の相互作用を阻害すると,動脈栓塞を予防することができます.

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