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Updated: Jun 23, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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タンパク質キナーゼの双価阻害剤を生成するための化学遺伝的方法

Zachary B Hill1, B Gayani K Perera, Dustin J Maly

  • 1Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195-1700, USA.

Journal of the American Chemical Society
|April 28, 2009
PubMed
まとめ

研究者は,双価キナーゼ阻害剤を作成するための新しい化学遺伝的方法を開発しました. これらの阻害剤は,小分子とペプチドを組み合わせて,SrcやAblのようなタンパク質キナーゼに対する効能と選択性を高めます.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.