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Updated: Jun 23, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
09:14

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Published on: February 16, 2018

二機能性アシルトランスフェラーゼ/デカルボキシラーゼLnmKは,ポリケチド生物合成におけるβ-アルキレーションの欠けているリンクである

Tao Liu1, Yong Huang, Ben Shen

  • 1Division of Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53705-2222, USA.

Journal of the American Chemical Society
|May 2, 2009
PubMed
まとめ

研究者らは,ポリケチド生物合成に不可欠な酵素であるLnmKを特定した. この二機能性アシルトランスフェラーゼ/デカルボキシラーゼ (AT/DC) 酵素はプロピオニル-アシルキャリアタンパク質 (ACP) を生成し,天然製品におけるβ-エチル分岐の起源を説明する.

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