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Updated: Jun 23, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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ゲノム全体でサポートされている精神病変異の神経機構

Christine Esslinger1, Henrik Walter, Peter Kirsch

  • 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany.

Science (New York, N.Y.)
|May 2, 2009
PubMed
まとめ

ZNF804A (rs1344706) の一般的な遺伝的変異は,健康な個体における脳の接続性に影響を及ぼします. 機能的結合におけるこの遺伝子用量依存の変異,特に背側前頭前皮質の変異は,精神病の神経遺伝的リスクメカニズムを示唆しています.

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