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Updated: May 1, 2026

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
08:01

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal

Published on: May 30, 2012

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マイクロRNA-145はOCT4,SOX2,KLF4を調節し,ヒト胚性幹細胞の多能性を抑制する

Na Xu1, Thales Papagiannakopoulos, Guangjin Pan

  • 1Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, The University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

Cell
|May 5, 2009
PubMed
まとめ

マイクロRNA-145 (miR-145) レベルは,ヒト胚性幹細胞の分化中に上昇し,OCT4,SOX2,KLF4をターゲットにすることで自己更新を抑制します. これは,幹細胞の発達に不可欠なフィードバックループを明らかにしています.

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