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関連する概念動画

DNA Packaging00:58

DNA Packaging

Overview
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
DNA Packaging00:58

DNA Packaging

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Updated: May 12, 2026

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
07:37

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

ゲノムの窓を開ける

Iestyn Whitehouse1, Toshio Tsukiyama

  • 1Sloan-Kettering Institute, New York, NY 12750, USA. whitehoi@mskcc.org

Cell
|May 5, 2009
PubMed
まとめ

クロマチン調節体は,遺伝子プロモーターの核細胞の位置を変化させることができます. この研究は,核子の位置づけが酵母における遺伝子調節にどのように影響するかを示しています.

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • エピジェネティクス エピジェネティクス

背景:

  • 核子の位置づけは,遺伝子発現を制御する上で極めて重要です.
  • 染色体構造が転写にどのように影響するかを理解することは,活発な研究分野です.

研究 の 目的:

  • ヌクレオソームの位置づけにおけるクロマチンの調節体の役割を調査する.
  • Saccharomyces cerevisiaeの転写調節に変化した核細胞位置が与える影響を実証する.

主な方法:

  • ゲノム全体で核細胞の位置をマッピングする.
  • 特定のクロマチンのレギュレータが遺伝子プロモーターに与える影響を分析する.

主要な成果:

  • 染色体調節剤は,多数の遺伝子のプロモーターにおける核細胞の位置を変化させることが判明した.
  • ヌクレオソームの位置の変化は,遺伝子調節に大きな影響を及ぼします.

結論:

  • 核子の位置づけは,染色体変形剤によって調節される重要なメカニズムです.
  • この研究は,転写制御を理解する上で,核細胞マッピングの力を強調しています.

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Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos
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Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

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Last Updated: May 12, 2026

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
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CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos
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Generation of Genome-wide Chromatin Conformation Capture Libraries from Tightly Staged Early Drosophila Embryos

Published on: October 3, 2018

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
10:16

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018