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The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton08:50

The Mechanics of (Poro-)Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

1.1K
In this work, an in vitro reconstitution approach is employed to study the poroelasticity of actomyosin gels under controlled conditions. The dynamics of the actomyosin gel and the embedded solvent are quantified, through which the network poroelasticity is demonstrated. We also discuss the experimental challenges, common pitfalls, and relevance to cell cytoskeleton...
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Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

3.5K
This protocol presents a method to perform rheology characterization of mucus that resides on gill rakers (GRs) of the silver carp. Viscoelastic characteristics of GR-mucus, obtained by measuring viscosity, storage and loss moduli, are evaluated for the apparent yield stress to understand the filter feeding mechanism in...
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The Diffusion of Passive Tracers in Laminar Shear Flow08:01

The Diffusion of Passive Tracers in Laminar Shear Flow

9.0K
A protocol for the study of the diffusion of passive tracers in laminar pressure-driven flow is presented. The procedure is applicable to various capillary pipe...
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Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

9.1K
Two different methods for characterizing the incipient particle motion of a single bead as a function of the sediment bed geometry from laminar to turbulent flow are...
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An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

9.0K
An experimentally accessible analog method for studying molecular hydrodynamic processes in dense fluids is presented. The technique uses particle image velocimetry of vibrated, high-restitution grain piles and allows direct, macroscopic observation of dynamical processes known and predicted to exist in strongly interacting, high density gases and...
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Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures10:56

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures

12.5K
Confocal microscopy is used to image quiescent and flowing colloid-polymer mixtures, which are studied as model systems for attractive suspensions. Image analysis algorithms are used to calculate structural and dynamic metrics for the colloidal particles that measure changes due to geometric...
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Updated: Jan 12, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

3.5K

HIV エントリー リビシテッド

Pradeep D Uchil1, Walther Mothes

  • 1Yale University School of Medicine, New Haven, CT 06536, USA.

Cell
|May 5, 2009
PubMed
まとめ
この要約は機械生成です。

ヒト免疫不全ウイルス (HIV) の宿主細胞への侵入が再調査されました. 新しい発見は,HIVが主に内分細胞を用いることを示唆しており,長年にわたって採用されてきた直接融合モデルに異議を唱えている.

さらに関連する動画

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

Published on: February 22, 2018

9.1K
An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

Published on: December 4, 2017

9.0K

関連する実験動画

Last Updated: Jan 12, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

3.5K
Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
11:51

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions

Published on: February 22, 2018

9.1K
An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

Published on: December 4, 2017

9.0K

科学分野:

  • ウイルス学 ウイルス学 ウイルス学
  • 細胞生物学 細胞生物学
  • 免疫学 免疫学とは

背景:

  • ヒト免疫不全ウイルス (HIV) は,伝統的に,プラズマ膜との直接融合を経て宿主細胞に侵入するウイルスとして研究されてきた.
  • このウイルスの侵入のモデルは広く受け入れられ,他の包装ウイルスにも適用されています.

研究 の 目的:

  • HIVが宿主細胞に侵入する主なメカニズムを調査する.
  • HIVの侵入のための直接的なプラズマ膜融合の確立されたモデルに異議を唱える.

主な方法:

  • ミヤウチ氏らによる研究. (2009) は,HIV-宿主細胞の相互作用を観察するために,高度なイメージングと細胞アッセイを使用しました.
  • ウイルスの侵入経路を解剖するために,特定の阻害剤と遺伝子操作が使用されました.

主要な成果:

  • 説得力のある証拠は,HIVが主に内分細胞分裂を通して細胞に侵入することを示しています.
  • この発見は,プラズマ膜での直接融合がHIV感染の主要な経路ではないことを示唆している.

結論:

  • HIV感染の流行モデルを改定する必要がある.
  • HIVの内細胞経路を理解することは,新しい抗ウイルス戦略の開発に不可欠です.