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Updated: May 6, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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SIRT5はカルバモイルリン酸合成酵素1をデアセチル化し,尿素循環を調節する

Takashi Nakagawa1, David J Lomb, Marcia C Haigis

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA.

Cell
|May 5, 2009
PubMed
まとめ

Sirtuin 5 (SIRT5) は,ミトコンドリア内のカルバモイルリン酸合成酵素1 (CPS1) を活性化させ,アンモニアの解毒に不可欠です. SIRT5欠乏症は,このプロセスを阻害し,断食や食事の変化でアンモニア濃度が上昇します.

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