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Updated: May 7, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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複数の遺伝子の突然変異は,拡散型大B細胞リンパ腫におけるNF-kappaBの放緩を引き起こします

Mara Compagno1, Wei Keat Lim, Adina Grunn

  • 1Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA.

Nature
|May 5, 2009
PubMed
まとめ

NF-kappaB経路のレギュレータ,特にA20遺伝子の遺伝子変異は,拡散型大B細胞リンパ腫 (DLBCL) で一般的です. これらの遺伝的病変は,NF-kappaBの活性化を長引かせ,リンパマゲネシスを促進します.

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