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Updated: Jun 23, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
06:40

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

螺旋状β-ペプチドの折りたたみによってガンマ分泌酵素の活性が抑制される

Yuki Imamura1, Naoto Watanabe, Naoki Umezawa

  • 1Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603.

Journal of the American Chemical Society
|May 13, 2009
PubMed
まとめ

螺旋状の構造を採用した新しいβ-ペプチド折合剤は,アルツハイマー病 (AD) 治療の重要な標的であるガンマ分泌酵素を効果的に阻害します. この発見は,新しいAD治療法と研究ツールの開発に有望なリードを提供します.

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