一般人口の肺動脈シストリック圧の年齢関連の増加
Carolyn S P Lam1, Barry A Borlaug, Garvan C Kane
1Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Circulation
|May 13, 2009
まとめ
肺動脈シストリック圧力 (PASP) は,年齢とともに増加し,より高い死亡リスクと関連しています. この研究では,PASPが潜在的心血管リスク因子であり,一般人口の治療目標であると強調しています.
科学分野:
- 心臓病学 心臓病学
- ゲロントロジーはゲロントロジーの学科です.
- 肺内科 肺内科 肺内科
背景:
- 肺動脈シストリック圧力 (PASP) の年齢関連の変化とその一般人口の予後効果に関するデータは限られている.
- 高齢者の全身性シストリック高血圧に関する研究は豊富ですが,肺循環の変化はあまり理解されていません.
- この研究は,PASPと高齢化との関係を調査し,その影響要因を特定し,死亡率に対する予測価値を評価することを目的とした.
研究 の 目的:
- 肺動脈収縮圧 (PASP) と一般人口の年齢との関係を定義する.
- PASPに影響を与える要因を特定する.
- PASPが死亡率の独立した予測要因であるかどうかを判断する.
主な方法:
- ミネソタ州オルムステッド郡の2,042人のランダムなサンプルに,エコーカルディオグラフィとスピロメトリーが行われました.
- 肺動脈シストリック圧力 (PASP) は,三回転回転速度を用いて測定した.
- 左心室の気圧 (E/e'比で推定される) と動脈の硬さ (腕動脈脈圧) も評価された.
主要な成果:
- 測定可能なPASPを有する1413人の被験者の中で,PASPの中央値は26mmHgであり,年齢とともに増加した (r=0.31,P<0.001).
- PASPの独立予測要因には,年齢,脈圧,およびミトラルE/e' (P<または=0.003) が含まれていた.
- PASPの上昇は,心肺疾患の既往症状のない被験者でも,より高い死亡率 (HR, 10 mm Hgあたり2.73; P<0.001) と有意に関連していました.
結論:
- この研究は,肺動脈の圧力の年齢関連の増加に関する最初の集団ベースの証拠を提供します.
- 肺動脈の圧力の上昇は,左心臓のダイアストリック圧力の上昇と全身血管硬化に関連しています.
- 肺動脈の圧力は,治療的標的として潜在的に心血管疾患の新たなリスク因子として浮上しています.
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