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Updated: Jun 23, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)
10:05

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)

Published on: January 20, 2016

DNAと細胞毒性ビスナフタリミドの相互作用を調節する間接的な効果は,2段階の結合プロセスを明らかにします

Luis González-Bulnes1, José Gallego

  • 1Centro de Investigacion Principe Felipe, Avda. Autopista del Saler 16, 46012 Valencia, Spain.

Journal of the American Chemical Society
|May 20, 2009
PubMed
まとめ

DNA配列の隣接する領域は,細胞毒薬エリナフィドの結合に影響する. A-経路を持つ不良配列は,薬物インターキャレーションを阻害し,DNA-薬物相互作用と安定性に影響を及ぼします.

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A Quantitative Assay to Study Protein:DNA Interactions, Discover Transcriptional Regulators of Gene Expression, and Identify Novel Anti-tumor Agents06:43

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