肥満と肥満関連の2型糖尿病の若者は,頸動脈の構造と機能の異常を示しています
Elaine M Urbina1, Thomas R Kimball, Connie E McCoy
1Department of Pediatrics, Cincinnati Children's Hospital and University of Cincinnati, Cincinnati, OH 45229, USA. Elaine.Urbina@cchmc.org
Circulation
|May 28, 2009
まとめ
肥満や2型糖尿病の若者は,早発性心血管疾患のリスクを示す,大動脈の厚さや硬さの増加を示しています. これらの変化は,脳卒中や心臓発作を予防するために早期介入の必要性を強調しています.
科学分野:
- 心血管の健康についてです.
- 小児内分泌学について
- 血管生物学 血管生物学
背景:
- 肥満や2型糖尿病 (T2DM) の成人は,脳卒中や心筋梗塞のリスクが高まります.
- 頸動脈内側介質の厚さ (cIMT) と動脈の硬さが増加することは,これらの有害な心血管的結果と関連しています.
- この研究では,痩せた,肥満,またはT2DM状態の青少年における頸動脈の特徴を調査しています.
研究 の 目的:
- 痩せた,肥満,T2DMの若者の頸動脈の構造と硬さを比較するために.
- これらのグループにおける頸動脈内膜の厚さと硬さの決定要因を特定する.
- 小児肥満とT2DMの早期血管変化を評価する.
主な方法:
- 頸動脈超音波は,痩せた182人,肥満136人,T2DM青年128人 (年齢10~24歳) でcIMTを測定するために使用されました.
- 計算された指標には,ヤング弾性分数とベータ硬さ指数が含まれています.
- アントロポメトリック,検査値,血圧,心血管リスク要因を評価した.
主要な成果:
- 肥満とT2DMの若者は,痩せた若者と比較して,大動脈内側介質の厚さ (cIMT) が大きいことを示した.
- 動脈は,肥満とT2DM群では,痩せた対照群よりも著しく硬くなった.
- 心血管疾患のリスク要因は,痩身から肥満からT2DMグループまで,徐々に悪化した.
結論:
- 肥満とT2DMを患っている若者は,頸動脈の異常な厚さと硬さがあります.
- これらの血管の異常は,従来の心血管の危険因子によって部分的にしか説明できない.
- 心血管疾患の危険因子の早期発見と管理は,将来の脳卒中と心筋梗塞を予防するために,これらの若者にとって極めて重要です.
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