関連する実験動画
Updated: Jun 22, 2026

11:19
Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
Published on: February 20, 2017
サイズとスピードは,サイトキネシスにおいて密接に関連しています
Martin Wühr1, Timothy J Mitchison, Christine M Field
1Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell
|June 4, 2009
まとめ
細胞分裂のプロセスであるサイトキネシスは,収縮環によって調節されます. 研究者らは,環の収縮率は細胞サイズに比例し,C. elegans.の異なる細胞サイズにわたって分裂時間を一貫させることを発見しました.
科学分野:
- 細胞生物学 細胞生物学
- 発達生物学 発達生物学について
- 遺伝学 遺伝学とは
背景:
- サイトキネシスは細胞分裂の基本的なプロセスであり,細胞の内容物の公平な分布を保証します.
- 動物の細胞では,このプロセスは主にアクチンとミオシン繊維で構成される収縮環の収縮によって引き起こされます.
- 細胞運動の調節メカニズムを理解することは,細胞の増殖と発達を理解するために不可欠です.
研究 の 目的:
- 細胞サイズと細胞運動の持続時間との関係を調べる.
- 皮質のリング収縮の速度を制御する要因を決定する.
- 細胞サイズの独立性のあるサイトキネシスを確保するメカニズムを解明する.
主な方法:
- 実験は,ネモトードであるCaenorhabditis elegans.の胚を用いて行われました.
- 皮質のリング収縮の速度は,サイトキネシスで測定されました.
- 最初の細胞周長は収縮率と相関していた.
主要な成果:
- サイトキネシス中の皮質環収縮の速度は,初期細胞周長と正比である.
- この関係は,細胞のサイズに関係なく,サイトキネシスの総持続時間が一定であることを保証します.
- カーヴァーホ et al. カーヴァーホ et al. (2009) は,細胞分裂のメカニズムに関する重要な洞察を提供します.
結論:
- サイトキネシスの持続時間は,収縮速度と初期細胞周周を結びつけるメカニズムにより,細胞サイズに無関係です.
- この発見は,細胞分裂と発達を理解する上で重要な意味を持つ.
- この研究は,細胞分裂中の皮質環の正確な調節を強調しています.
関連する概念動画
Anaphase A and B
Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
Anaphase A and B
Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
The Contractile Ring
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
The Contractile Ring
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
Mitosis and Cytokinesis
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis
In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

