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チャペロニンの過剰発現は遺伝的多様性と酵素の進化を促進します

Nobuhiko Tokuriki1, Dan S Tawfik

  • 1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

Nature
|June 5, 2009
PubMed
まとめ

E. coli のようなチャペロニンは,GroEL/GroES のバッファー変異を起こし,進化のスピードを早める. これらの熱ショックタンパク質の過剰発現は,不安定なタンパク質の変種の折り畳みを助けることによって,酵素適応を加速します.

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