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Updated: Jun 22, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

IRAPは,MHCクラスIのクロスプレゼンテーションに必要なエンドソーマ区画を特定します

Loredana Saveanu1, Oliver Carroll, Mirjana Weimershaus

  • 1INSERM, U580, 75015 Paris, France; Université Paris Descartes, Faculté de Médecine René Descartes, 75015 Paris, France.

Science (New York, N.Y.)
|June 6, 2009
PubMed
まとめ

インスリン調節アミノペプチダゼ (IRAP) は,メジャー・ヒストコンパティビリティ・コンプレックス (MHC) クラスIの分子のためにエンドソーム内のペプチドをトリミングすることによって,クロスプレゼンテーションにおいて重要な役割を果たします. この発見は,抗原プレゼンテーションに関与する細胞区間を明確にします.

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