関連する実験動画

Updated: May 5, 2026

Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging
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Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging

Published on: December 1, 2011

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HIVカプシドのヘクサアメリカン構成要素のX線構造

Owen Pornillos1, Barbie K Ganser-Pornillos, Brian N Kelly

  • 1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Cell
|June 16, 2009
PubMed
まとめ

研究者らは,HIVカプシドタンパク質ヘクサマーの原子構造を決定し,ウイルス組成と潜在的な薬物標的の洞察を明らかにした. この研究は,レトロウイルスのカプシド形成と抑制戦略の理解を前進させる.

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Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction12:38

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction

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Analyzing and Building Nucleic Acid Structures with 3DNA16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

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Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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The Nucleosome Core Particle01:12

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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