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Updated: Jun 22, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

アシルトランスフェラーゼ媒介によるポリケチドが,真菌のメガシンタゼから放出されます

Xinkai Xie1, Michael J Meehan, Wei Xu

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|June 18, 2009
PubMed
まとめ

研究者らは,真菌酵素LovFが,アシルトランスフェラーゼLovDを用いてその産物を放出する方法を解明した. このアシルトランスフェラーゼ媒介の放出メカニズムは,コレステロールを下げる薬であるロバスタチン (lovastatin) の生成のための触媒効率を高めます.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products07:59

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