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マクロファージのエラスタゼは,ネズミのマクロファージ内の細菌を殺します

A McGarry Houghton1, William O Hartzell, Clinton S Robbins

  • 1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. houghtonm@dom.pitt.edu

Nature
|June 19, 2009
PubMed
まとめ

マトリックスメタルプロテインアース12 (MMP12) は,細胞膜を破壊することによって,直接細菌を殺します. MMP12は,マクロファージの抗菌防御に不可欠であり,そのカルボキシ末端ドメインがこの活動を媒介する.

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