変位タンパク質 (18 kD) は,ベンゾジアゼピンのような副作用のない抗不安薬の標的である
Rainer Rupprecht1, Gerhard Rammes, Daniela Eser
1Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Nussbaumstrasse 7, Munich 80336, Germany. rainer.rupprecht@med.uni-muenchen.de
Science (New York, N.Y.)
|June 23, 2009
まとめ
転位タンパク質 (18 kD) を標的とする新しい抗不安薬が有望である. XBD173のようなこれらの化合物は,従来のベンゾジアゼピンとは異なり,鎮静剤や離脱剤なしで,迅速に作用する不安緩和を提供する.
科学分野:
- 神経科学は神経科学である.
- 薬理学 薬理学とは
背景:
- ベンゾジアゼピンなどのほとんどの抗不安薬は,脳の神経伝達物質を調節する.
- 長期にわたるベンゾジアゼピン使用は,耐性および離脱につながる.
- トランスロケータータンパク質 (18 kD) のリガンドは,神経ステロイド合成を刺激し,抗不安効果をもたらす可能性があります.
研究 の 目的:
- トランスロケータータンパク質 (18 kD) リガンドの抗不安作用の可能性を調査する.
- ベンゾジアゼピンと比較してXBD173の有効性と副作用プロフィールを評価する.
主な方法:
- 転位タンパク質 (18 kD) リガンドXBD173を歯類とヒトに投与した.
- 評価されたガンマ-アミノバター酸媒介神経伝達.
- 誘発パニック発作,鎮静,離脱症状に対する評価効果.
主要な成果:
- XBD173は,歯類におけるガンマ-アミノバター酸媒介神経伝達を強化した.
- XBD173は,鎮静剤や耐性のないネズミで誘発されたパニック発作を相殺しました.
- XBD173は,鎮静剤や離脱症状なしに,ヒトにおける抗パニック作用を示した.
結論:
- XBD173のようなトランスロケータータンパク質 (18 kD) リガンドは,効果的な抗不安薬である.
- XBD173は,副作用が少ないベンゾジアゼピンに代わる潜在的な選択肢を提供します.
- これらのリンガンドは,迅速に作用する抗不安薬の有望な候補である.
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