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Updated: Jun 22, 2026

Modeling Ligands into Maps Derived from Electron Cryomicroscopy
09:30

Modeling Ligands into Maps Derived from Electron Cryomicroscopy

Published on: July 19, 2024

デンドリット分子とDNAの間の多価認識をモデル化:リガンドの"犠牲"とスクリーニングが結合を強化する方法を理解する

Giovanni M Pavan1, Andrea Danani, Sabrina Pricl

  • 1Molecular Simulations Engineering (MOSE) Laboratory, Department of Chemical Engineering (DICAMP), University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy. giovanni.pavan@supsi.ch

Journal of the American Chemical Society
|June 27, 2009
PubMed
まとめ

分子ダイナミクスのシミュレーションにより,精子基を持つデンドリート分子がDNAに結合する仕組みが明らかになりました. この研究は,リガンド"犠牲"とスクリーニングが,高塩分濃度でもDNA結合親和性を高める多価性における新しいパラダイムを導入しています.

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