関連する実験動画

Updated: Jun 22, 2026

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays
08:27

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Published on: October 20, 2023

ER-ミトコンドリアの結合複合体は,合成生物学スクリーンで明らかになりました

Benoît Kornmann1, Erin Currie, Sean R Collins

  • 1Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA. benoit.kornmann@ucsf.edu

Science (New York, N.Y.)
|June 27, 2009
PubMed
まとめ

研究者らは,タンパク質複合体 (Mmm1/Mdm10/Mdm12/Mdm34) を特定し,それは,エンドプラズマ網膜 (ER) とミトコンドリアを結びつける分子鎖として作用する. この発見は,臓器細胞の伝達と細胞機能におけるその役割に光を当てています.

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A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics10:31

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Mitochondrial Protein Sorting

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Translocation of Proteins into the Mitochondria

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The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
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Protein Transport into the Inner Mitochondrial Membrane

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