ミトコンドリアのSTAT3は,Rasに依存した腫瘍性変異をサポートしています
Daniel J Gough1, Alicia Corlett, Karni Schlessinger
1Department of Pathology and New York University Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Science (New York, N.Y.)
|June 27, 2009
まとめ
シグナルトランスデューサーとトランスクリプションアクティベーター3 (STAT3) は,Ras駆動がんをサポートします. STAT3では,STAT3が表示される.
科学分野:
- 分子生物学は分子生物学である.
- がん研究 がん研究
- 細胞生物学 細胞生物学
背景:
- シグナルトランスデューサーおよびトランスクリプションアクティベーター3 (STAT3) は,リン酸化によって活性化されるトランスクリプション因子です.
- STAT3は通常,遺伝子発現を調節するために核に転位する.
- Rasオンコタンパク質は,悪性変異の原動力として知られています.
研究 の 目的:
- ラス媒介の悪性変異におけるSTAT3の役割を調査する.
- Ras変換のためにSTAT3の正規核機能が必要かどうかを判断する.
- 癌におけるSTAT3の非正規的機能を調査する.
主な方法:
- Ras変換細胞モデルを使用した.
- フォスフォリレーション,核転位,またはDNA結合が低下したSTAT3変異体を使用しています.
- 細胞生物学技術を用いてSTAT3の局所化を調査した.
- グライコリシスと酸化性リン酸化を含む代謝変化の評価.
主要な成果:
- ラス媒介型変換は,STAT3.3が存在しない場合に障害がありました.
- カノニカルな機能が欠けているSTAT3変異体は,まだRas変換をサポートしています.
- STAT3は核転位とは独立してミトコンドリアで見つかりました.
- STAT3をミトコンドリアにのみターゲットにすることで,Ras変換が容易になりました.
- ミトコンドリアのSTAT3ががんに関連する代謝経路を調節する.
結論:
- STAT3は,その核転写活動を超えて,Ras媒介の悪性変異において重要な役割を果たします.
- STAT3は,がん代謝をサポートするミトコンドリア内の非正規の機能を持っています.
- ミトコンドリアのSTAT3は,がん細胞の生存と増殖に不可欠な代謝再プログラムに直接貢献します.
関連する概念動画
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03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:22PI3K/mTOR/AKT Signaling Pathway
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02:38The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...