関連する実験動画

Updated: Jun 22, 2026

Methods to Identify the NMR Resonances of the 13C-Dimethyl N-terminal Amine on Reductively Methylated Proteins
13:59

Methods to Identify the NMR Resonances of the 13C-Dimethyl N-terminal Amine on Reductively Methylated Proteins

Published on: December 12, 2013

メチル共酵素M還元酵素のメカニズムにはNi-メチル中間体があるのでしょうか?

Shi-lu Chen1, Vladimir Pelmenschikov, Margareta R A Blomberg

  • 1Department of Physics, Stockholm University, SE-10691 Stockholm, Sweden. shlchen@physto.se

Journal of the American Chemical Society
|July 3, 2009
PubMed
まとめ

メチル-コエンザイムM還元酵素 (MCR) のメチル-ニール (Methyl-Ni(F(430)) の形成は,基質の酸性に依存する. メチルハリドはこれを促進するが,原生基板はエネルギー的にアクセス不能であり,実験結果と一致する.

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