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Operant Procedures for Assessing Behavioral Flexibility in Rats
Published on: February 15, 2015
規則に基づく行動の分断可能な構成要素は,明確な中部と前頭前部の領域に依存しています
Mark J Buckley1, Farshad A Mansouri, Hassan Hoda
1Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK. buckley@psy.ox.ac.uk
まとめ
主要スルクスの損傷は,作業記憶における規則維持に影響し,軌道前頭皮質の損傷は報酬に基づく規則更新に影響し,ACCスルクスの損傷は,意思決定のための選択結果の参照に影響した.
科学分野:
- 神経科学は神経科学である.
- 認知心理学とは,認知心理学である.
- 霊長類の神経生理学
背景:
- 規則に基づく行動は,複雑な意思決定に不可欠です.
- 前頭前皮質 (PFC) と前帯状皮質 (ACC) は,ルールによる行動を実装することが知られている.
- PFCとACCにおける特定の地域貢献は不明である.
研究 の 目的:
- 規則に基づく行動における特定の前頭前頭部およびACCサブ領域の異なる役割を明らかにする.
- 人間の神経心理学と非人間の霊長類の神経生理学の間の発見を橋渡しする.
- ルールに基づく意思決定の認知的要素に対する制限された病変の影響を調査する.
主な方法:
- ウィスコンシン・カード・ソルティング・テスト (WCST) アナログをマカカで使った.
- 特定の脳領域に限定された損傷を施した:軌道前頭皮質 (OFC),主 (PS),上部ドロソラテラルPFC,腹側PFC,ACC.
- 傷害後のルール主導行動の分離可能な認知要素の評価.
主要な成果:
- 主要硫黄 (PS) 病変は,特に作業記憶における抽象的な規則の維持を阻害しました.
- 軌道前頭皮質 (OFC) の病変は,規則値表現の迅速な報酬ベースの更新を選択的に妨げました.
- 前帯状皮質 (ACC) の軟骨損傷は,意思決定中に最近の選択結果の積極的な参照を妨げました.
結論:
- PFCとACCの異なるサブリージョンは,ルールに基づく行動の実施において,異なる重要な役割を果たしています.
- PSはルール維持,OFCは価値更新,ACCは結果に基づく意思決定に不可欠です.
- これらの発見は,神経学的状態で観察される規則による行動の欠陥を理解するための神経生理学的基礎を提供します.
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