Co (II) と Zn (II) がバチルス・アンスラシスからメタロベータ・ラクタマゼBla2に差異的に結合する

Megan J Hawk1, Robert M Breece, Christine E Hajdin

  • 1Department of Chemistry and Biochemistry, 160 Hughes Hall, Miami University, Oxford, Ohio 45056, USA.

まとめ

バシルス・アントラシス・メタロベータ・ラクトマゼ Bla2は亜鉛とコバルトを異なる形で結合する. モノ-亜鉛Bla2は活性であるが,ダイ-亜鉛Bla2は不安定であり,この酵素における亜鉛とコバルトの金属結合機構が異なっている.

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