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Updated: Jun 21, 2026

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オピオイド離脱後のシナプス長期増強の誘導

Ruth Drdla1, Matthias Gassner, Ewald Gingl

  • 1Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria.

Science (New York, N.Y.)
|July 11, 2009
PubMed
まとめ

ミュオピオイド受容体 (MOR) アゴニストを突然停止すると,痛みの経路に長期的な増強 (LTP) が起こり,オピオイド誘発性過敏症 (OIH) に繋がります. 縮小型離脱はこれを防止し,オピオイドの副作用を管理するための新しいターゲットを提供します.

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