bcl-2トランスゲンはT細胞死亡を阻害し,胸膜の自己検閲を妨害する
A Strasser1, A W Harris, S Cory
1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Victoria, Australia.
Cell
|November 29, 1991
まとめ
bcl-2遺伝子はTリンパ球の生存を促進し,マウスの免疫反応を強化する. これは,BCL-2発現がリンパ球の生死を調節する鍵であることを示唆しています.
科学分野:
- 免疫学 免疫学とは
- 分子生物学は分子生物学である.
- 細胞生物学 細胞生物学
背景:
- ほとんどの発達中のTリンパ球はアポトーシスを経験する.
- bcl-2遺伝子はアポトーシスを抑制し,細胞生存を促進することが知られている.
研究 の 目的:
- Tリンパ球の生存と機能に対するbcl-2発現の影響を調査する.
- bcl-2がT細胞の分化と免疫応答に影響するかどうかを判断する.
主な方法:
- Tリンパ系コンパートメントでE mu-bcl-2を発現するトランスジェニックマウスが生成されました.
- T細胞の生存能力,分化,およびリンパ毒性物質に対する耐性を in vitro で評価した.
- 免疫に対する免疫反応と,胸腺とリンパ節のT細胞集団を分析した.
主要な成果:
- E mu-bcl-2トランスジェニックマウスのT細胞は,持続的な生存能力と自発的な微分化を示した.
- これらのT細胞は,リンパ毒性物質によって殺されるのに抵抗性がありました.
- 総T細胞数と胸膜内転は変化しなかったが,免疫への反応は強化された.
- 自己超抗原反応性T細胞の過剰は,胸腺にみられたが,リンパ節にはみられなかった.
結論:
- 調節されたbcl-2発現はTリンパ球の生存と機能に大きく影響する.
- 強化されたbcl-2発現は,T細胞の生存率を向上させ,免疫反応を強化する.
- これらの発見は,bcl-2がリンパ球ホメオスタシスの重要な調節因子であることを示している.
関連する概念動画
Cell-mediated Immune Responses
85.0K
Overview
85.0K
Abnormal Proliferation
5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Cytotoxic T Cells-mediated Immune Response
7.7K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.7K
T Cell Activation and Clonal Selection
16.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
16.7K
The Intrinsic Apoptotic Pathway
8.9K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
8.9K
T Cell Types and Functions
2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K


