長期にわたる中枢静脈カテーテルによる閉塞と血栓の管理
Jacquelyn L Baskin1, Ching-Hon Pui, Ulrike Reiss
1Department of Oncology and International Outreach Program, St Jude Children's Research Hospital, Memphis, TN 3105-2794, USA.
Lancet (London, England)
|July 15, 2009
まとめ
中枢静脈カテーテル (CVCs) は閉塞したり,血栓を形成したりすることがあり,血栓の阻害に対して血栓解離剤のような特殊な治療が必要となる. 予防戦略は,適切なカテーテル設置と感染制御に焦点を当てており,現在,抗凝固予防は推奨されていません.
科学分野:
- 血管医学 血管医学とは
- 介入放射線学とは,介入放射線学です.
- ネフロロジーはネフロロジーを用います.
背景:
- 長期中央静脈カテーテル (CVC) は慢性疾患の管理に不可欠ですが,合併症に罹患する傾向があります.
- カテーテル閉塞およびカテーテル関連の血栓は,CVCの機能と患者の健康に影響を与える頻繁な問題です.
研究 の 目的:
- CVCの閉塞およびカテーテル関連の血栓の管理戦略をレビューし,要約する.
- これらのCVC合併症の危険因子,診断方法,治療オプションについて議論します.
主な方法:
- CVC閉塞と血栓の管理に関する現在の証拠を要約した文献レビュー.
- ドップラー超音波検査と静脈検査を含む診断技術の分析.
- 血栓解消療法と抗凝固薬を含む治療方法の評価.
主要な成果:
- 機械的なCVC閉塞は,特定の原因に合わせた治療を必要とします.
- 血栓閉塞は通常,アルテプラスなどの血栓解消剤に良好な反応を示します.
- カテーテル関連の血栓は,以前の感染や位置不良などの要因と関連しており,肺栓塞などの深刻な結果につながる可能性があります.
結論:
- CVCの閉塞および血栓の効果的な管理には,標的治療が必要です.
- CVCを適切に配置し,感染を抑制するなど,予防的な対策が不可欠です.
- 血栓解離性予防は,CVC感染と血栓の予防に有望であることが示されているが,さらなる研究と費用対効果に関する研究が必要である.
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