ミエロイド関連タンパク質-8/14は,血管損傷に対する生物学的反応に不可欠です
Kevin Croce1, Huiyun Gao, Yunmei Wang
1Director, Case Cardiovascular Center, Herman K. Hellerstein Professor of Cardiovascular Research, Case Western Reserve University School of Medicine, Division of Cardiovascular Medicine, 11100 Euclid Ave, LKS 3001, Cleveland, OH 44106-5038, USA.
Circulation
|July 22, 2009
まとめ
ミエロイド関連タンパク質 (MRP)-8/14は,血管の炎症と白血球の徴募を調節する. MRP-8/14が欠けていたマウスは,血管炎症と損傷反応の減少を示し,心臓血管疾患におけるその役割を示している.
科学分野:
- 血管生物学 血管生物学
- 炎症の研究 炎症の研究
- 心血管科学 心血管科学
背景:
- ミエロイド関連タンパク質 (MRP) -8 (S100A8) とMRP-14 (S100A9) は,ミエロイド細胞機能と炎症に関与するS100タンパク質です.
- 高いMRP-8/14レベルは心血管疾患を予測しますが,血管疾患における直接的な役割は不明です.
研究 の 目的:
- 血管の炎症と疾患におけるMRP-8/14の直接的な役割を調査する.
- MRP-8/14欠乏が血管損傷,血管炎,動脈硬化への反応に与える影響を評価する.
主な方法:
- 血管損傷,血管炎,動脈硬化症のモデルを使用して,野生型およびMRP-14欠乏のマウスにおける血管炎の評価.
- 白血球の蓄積,細胞増殖,ネオインティマルの形成,病変の重症度,動脈硬化性プラークの発達を評価した.
主要な成果:
- MRP-14欠乏したマウスは,動脈損傷後に白血球の蓄積,増殖,およびネオインティマルの形成が低下した.
- MRP-8/14が欠けていたマウスは,血管炎モデルで中性粒子の蓄積と病変の重度の低下を示した.
- アポリポプロテインEとMRP-8/14の併合欠乏は,動脈硬化性損傷領域とマクロファージの蓄積を弱めた.
結論:
- MRP-8/14は血管の炎症を広く調節する.
- MRP-8/14複合体は,白血球の募集を促進することによって,血管損傷に対する生物学的反応に貢献します.
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