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Updated: Jun 21, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

RNAポリメラーゼIIIは,細胞塩基DNAを検知し,RIG-I経路を通ってI型インターフェロンを誘導する

Yu-Hsin Chiu1, John B Macmillan, Zhijian J Chen

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Cell
|July 28, 2009
PubMed
まとめ

細胞塩基DNAは,RNAポリメラーゼIII (Pol-III) 経由で5'-トリフォスファートRNA (5'-pppRNA) に変換され,インターフェロン反応を誘発する. このRNAはRIG-I経路を活性化し,Pol-IIIをハイライトします.

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A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

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