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Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
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リボフラビンキナーゼはTNF受容体1とNADPH酸化酵素を結合する

Benjamin Yazdanpanah1, Katja Wiegmann, Vladimir Tchikov

  • 1Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.

Nature
|July 31, 2009
PubMed
まとめ

リボフラビンキナーゼ (RFK) は,腫瘍死滅因子受容体1 (TNFR1) を,細胞防御における重要な酵素であるNADPH酸化酵素と接続する架け橋として作用する. この相互作用は,TNF誘発反応性酸素種 (ROS) の生成において,NADPH酸化酵素にFADの組み込みを強化することによって極めて重要です.

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