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関連する概念動画

Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Structure of a Gene01:30

Structure of a Gene

A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people contain the same genes, there is a small fraction that is slightly different amongst people. A gene with a small difference in its sequence of DNA bases forms different alleles, contributing to different phenotypes.
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...

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関連する実験動画

Updated: Jun 21, 2026

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards
10:50

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards

Published on: February 25, 2017

共通の規制変異は,細胞タイプに依存した方法で遺伝子発現に影響を与えます.

Antigone S Dimas1, Samuel Deutsch, Barbara E Stranger

  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1HH, Cambridge, UK.

Science (New York, N.Y.)
|August 1, 2009
PubMed
まとめ

遺伝的多様性を理解する

さらに関連する動画

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

関連する実験動画

Last Updated: Jun 21, 2026

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards
10:50

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards

Published on: February 25, 2017

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • 人間の遺伝学 人間の遺伝学

背景:

  • 遺伝的変異は,人間の現象型や病気に影響を与えます.
  • 機能的変異は,組織特異的な方法で作用する可能性があります.

研究 の 目的:

  • 遺伝子発現に対する細胞タイプ特異的な遺伝効果を調査する.
  • 調節変種と,異なる細胞タイプにおける遺伝子発現との関連を特定する.

主な方法:

  • 遺伝子発現プロファイリングは,75人の3つの細胞タイプで実施されました.
  • 遺伝子変異 (単核型多型) と遺伝子発現レベルとの間の関連分析が行われました.
  • エクスプレッシブ量的な特征局部 (eQTLs) を特定し,それらの細胞タイプ特異性を分析した.

主要な成果:

  • 69-80%の規制変異は,細胞タイプ特異的な効果を示した.
  • 遺伝子ごとに複数のeQTLが特定され,一部のeQTLはユニークで,一部のeQTLは細胞種間で共有されています.
  • 細胞タイプに特異的なeQTLは,より小さな効果サイズを持つ遺伝子からより大きな距離で見つかりました.

結論:

  • 遺伝子発現の調節は,細胞タイプの文脈によって著しく影響を受けます.
  • 規制変異の包括的な理解には,細胞タイプ特異的な分析が必要です.
  • このアプローチは,人間の特徴に影響を与える規制の多様性のより広いレパートリーを明らかにします.