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Updated: Jun 21, 2026

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
10:40

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

Published on: December 21, 2019

HIV-1プロテアゼの基質結合機構は,明示的な溶媒原子模擬から得られた

Fabio Pietrucci1, Fabrizio Marinelli, Paolo Carloni

  • 1International School for Advanced Studies (SISSA-ISAS), via Beirut 2-4, I-34014 Trieste, Italy.

Journal of the American Chemical Society
|August 4, 2009
PubMed
まとめ

この研究は,ペプチド基板が分子動態を用いて野生型のHIV-1プロテアゼに結合する方法を明らかにしています. この発見は,突然変異が天然基板とペプチドミメティックとの結合に異なった影響を与える可能性があることを示唆している.

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