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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

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関連する実験動画

Updated: Jun 21, 2026

In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers
13:10

In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers

Published on: August 1, 2014

周期性トリガーによって負荷されたクラスIメジャーヒストコンパティビリティ複合体.

Boris Rodenko1, Mireille Toebes, Patrick H N Celie

  • 1Division of Cell Biology II, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Journal of the American Chemical Society
|August 7, 2009
PubMed
まとめ
この要約は機械生成です。

研究者は,定義されたペプチド-MHCsを作成するための新しい化学トリガー方法を開発し,T細胞療法や高通量スクリーニングなどのアプリケーションのためのUVベースのアプローチの限界を克服しました.

さらに関連する動画

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

関連する実験動画

Last Updated: Jun 21, 2026

In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers
13:10

In Situ Detection of Autoreactive CD4 T Cells in Brain and Heart Using Major Histocompatibility Complex Class II Dextramers

Published on: August 1, 2014

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

科学分野:

  • 免疫学 免疫学とは
  • 構造生物学 構造生物学とは
  • バイオケミストリー バイオケミストリー

背景:

  • クラスIメジャー・ヒストコンパティビリティ・コンプレックス (MHCs) は,細胞毒性T細胞にペプチドを提示するために重要である.
  • 再結合MHCを生成するための現在の方法は,過剰なペプチドでインビトロ再折りを必要とし,高通量生産を制限します.
  • フォトケージリガンドは,条件付きのMHCリガンド交換を提供しますが,紫外線光の浸透と細胞培養における熱の問題によって妨げられます.

研究 の 目的:

  • 定義されたペプチド-MHCsを生成するための新しい化学トリガー誘発方法を開発する.
  • MHC複合体生産のためのUVベースのリガンド交換の限界を克服するために.
  • T細胞治療と高通量スクリーニングにおけるアプリケーションを可能にします.

主な方法:

  • MHC分子のための新しい化学感受性リガンドの設計と合成.
  • MHC-リガンド複合体の結晶学分析により,結合部位の占有率とリガンドの反応性を確認する.
  • T細胞検出のためのペプチド-MHCsを生産するための化学トリガーメソッドの検証.

主要な成果:

  • 結晶構造は,化学感受性リガンドがMHCに反応性構造で結合することを確認した.
  • 化学トリガー法では,定義ペプチドMHCsを成功裏に生成しました.
  • 生成されたペプチド-MHCは,T細胞検出のために検証されました.

結論:

  • 化学トリガー誘発リガンド交換は,定義されたペプチド-MHCsを生成するための汎用的で適用可能な方法を提供します.
  • この技術は,細胞療法におけるT細胞の拡張と浄化のために,細胞培養にMHCの負荷を容易にします.
  • この方法論は,MHCリガンドの高通量スクリーニングのための小型化されたシステムの開発をサポートします.